Mascia Maria Paola
Senior research scientist
Cittadella Universitaria di Monserrato
S.S. 554, Km 4,5
09042 Monserrato (CA)
Modulation of recombinant receptors and ion channels by pharmacologically active molecules
The main goal of the laboratory centers on the modulatory action, by pharmacologically active compounds, of different receptors and channels, particularly the inhibitory g-aminobutyric acid type A (GABAA) and the strychnine sensitive glycine receptors. I am mainly interested in the characterization and identification of novel lead molecules for the development of novel drugs.
My laboratory employs the two-electrode voltage clamp technique after microinjection of cDNA or cRNA and expression of receptors and channels into Xenopus laevis oocytes
Mascia MP, Asproni B, Busonero F,Talani G, Maciocco E, Pau A, Cerri R, Sanna E, Biggio G.(2005).
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. Eur J Pharmacol 516:204-211
Mascia MP, Bachis E, Obili N, Maciocco E, Cocco GA, Sechi GP, Biggio G. (2007).
Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes. Eur J Pharmacol. 558:37-42
Anzini M, Valenti S, Braile C, Cappelli A, Vomero S, Alcaro S, Ortuso F, Marinelli L, Limongelli V, Novellino E, Betti L, Giannaccini G, Lucacchini A, Daniele S, Martini C, Ghelardini C, Di Cesare Mannelli L, Giorgi G,Mascia MP, Biggio G. (2011)
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.J Med Chem. 54: 5694-5711
Mascia MP, Fabbri D, Dettori M A,Ledda G, Delogu G, Biggio G. (2012).
Hydroxylated biphenyl derivatives are positive modulators of human GABA(A) receptors.Eur J Pharmacol. 693: 45-50