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Maccioni Paola

Paola MaccioniResearch scientist
Cittadella Universitaria di Monserrato
S.S. 554, Km 4,5
09042 Monserrato (CA)
Tel 070-6753169
Fax 070-6754320
This email address is being protected from spambots. You need JavaScript enabled to view it.


Neurobiology of alcoholism


Research summary

As member of the Colombo lab, my major research topics focus on the following:
-  Investigation of the role of the GABAB receptor in the mediation of the central effects of alcohol
-  Investigation of the neurochemical and behavioral bases underlying alcohol abuse and dependence
-  Identification of novel pharmacotherapies for alcoholism
-  Set up and validation of animal and experimental models of alcoholism
-  Investigation of the neurobiological bases underlying food intake and drug addiction


Representative publications

Maccioni P., Lorrai I., Marras M.F., Contini A., Capra A., Piras G., Caboni P., Gessa G.L., Colombo G., Elevated reinforcing and motivational properties of alcohol at the end of the nocturnal period in sP rats. Psychopharmacology 232:3585-3595, 2015.

Maccioni P., Vargiolu D., Thomas A.W., Malherbe P., Mugnaini C., Corelli F., Leite-Morris K.A., Gessa G.L., Colombo G., Inhibition of alcohol self-administration by positive allosteric modulators of the GABAB receptor in rats: Lack of tolerance and potentiation of baclofen. Psychopharmacology 232:1831-1841, 2015.

Maccioni P., Zaru A., Loi B., Lobina C., Carai M.A.M., Gessa G.L., Capra A., Mugnaini C., Pasquini S., Corelli F., Hyytiä P., Lumeng L., Colombo G., Comparison of the effect of the GABAB receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats. Alcohol. Clin. Exp. Res. 36:1748-1766, 2012.

Maccioni P., Colombo G., Riva A., Morazzoni P., Bombardelli E., Gessa G.L., Carai M.A.M., Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats. Br. J. Nutr. 104:624-628, 2010.

Maccioni P., Pes D., Carai M.A.M., Gessa G.L., Colombo G., Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-flavoured beverage in rats. Behav. Pharmacol. 19:197-209, 2008.


Lab team



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