Questo sito utilizza i cookies per agevolarti nella navigazione, se non sei d'accordo, ti preghiamo di chiudere immediatamente la pagina.

Massimino Maria Lina

foto okResearch scientist
c/o Complesso Biologico Interdipartimentale
A. Vallisneri
Viale Giuseppe Colombo 3
35121 Padova
Tel 049-8276141
Fax 049-8276343
This email address is being protected from spambots. You need JavaScript enabled to view it.


 Prion protein and neurodegeneration


Research summary

  • Neurodegenerative disorders, with particular emphasis to prion diseases and the pathophysiology of the prion protein.
  • Pathophysiology of the skeletal muscle

 foto Immagine1

Main experimental models

  • primary cell cultures from different tissues (different neuronal types, cortical and spinal astrocytes, microglia, macrophages and myocytes)
  • In vivo models of genetically modified mice


involved in research projects of the
group of Prof. Sorgato






Representative publications

Massimino ML, Peggion C, Loro F, Stella R, Megighian A, Scorzeto M, Blaauw B, Toniolo L, Sorgato MC, Reggiani C, Bertoli A., Age-dependent neuromuscular impairment in prion protein knock-out mice. Muscle Nerve. 53, 269-79, 2016.

De Mario A, Castellani A, Peggion C, Massimino ML, Lim D, Hill AF, Sorgato MC, Bertoli A., The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase.
Front Cell Neurosci. 2015 Oct 28;9:416. doi: 10.3389/fncel.2015.00416. eCollection 2015.

Zanetti F, Carpi A, Menabò R, Giorgio M, Schulz R, Valen G, Baysa A, Massimino ML, Sorgato MC, Bertoli A, Di Lisa F. , The cellular prion protein counteracts cardiac oxidative stress.Cardiovasc Res. 104, 93-102, 2014. 

Massimino ML, Redaelli M, Bertoli A, Sorgato MC, Mucignat-Caretta C., Altered behavioral aspects of aged mice lacking the cellular prion protein. Physiology and Behavior, 119, 86-91, 2013.

Lazzari C, Peggion C, Stella R, Massimino ML, Lim D, Bertoli A, Sorgato MC., Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons.J Neurochem. 116, 881-90, 2011.

Stella R, Massimino ML, Sorgato MC, Bertoli A., Prion and TNFα: TAC(E)it agreement between the prion protein and cell signaling.Cell Cycle, 9, 4616-21, 2010

Stella R, Massimino ML, Sandri M, Sorgato MC, Bertoli A., Cellular prion protein promotes regeneration of adult muscle tissue. Mol Cell Biol. 30, 4864-76, 2010.

Massimino ML, Ferrari J, Sorgato MC, Bertoli A., Heterogeneous PrPC metabolism in skeletal muscle cells.FEBS Lett, 580, 878–884, 2006.