Chelini Gabriele
- Dettagli
- Visite: 489
Research scientist
Via Giuseppe Moruzzi, 1
56124 - Pisa
Fax 0503153220
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Research topic
Permanent shift in synaptic strength is a key prerogative of the central nervous system that allows brain circuits to constantly change in response to life-experiences. Studies show that a fine-tuned balance between synaptic potentiation and depression is a crucial component in learning. When a stimulus triggers a localized event of synaptic potentiation (LTP), this is immediately followed by a “rebound” heterosynaptic depression (hLTD), necessary to maintain circuit homeostasis.
Experience-dependent changes in efficacy requires massive reshaping of synaptic morphology that is strongly influenced by the spatial arrangement of locally coordinated synapses. This homeostatic process of synaptic clustering is pivotal for learning, memory and optimization of perceptive skills. Conversely, altered synaptic morphology and clustering is a neuropathological hallmark in several neuropsychiatric disorders.
My primary research interest is to understand how the morphology and spatial arrangement of synapses contribute to meaningful changes in animal behavior, balancing stability and flexibility based on adaptive needs, and how deviation from this balance exacerbates in behavioral hallmarks relevant to psychopathology
List of the most relevant peer-reviewed publications
Chelini, G., Mirzapourdelavar, H., Durning, P., Baidoe-Ansah, D., Sethi, M.K., O’Donovan, S.M., Klengel, T., Balasco, L., Berciu, C., Boyer-Boiteau, A., et al. (2024). Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice. Cell Reports 43, 114112. https://doi.org/10.1016/j.celrep.2024.114112.
Chelini, G.*, Trombetta, E. M., Fortunato-Asquini, T., Ollari, O., Pecchia, T., & Bozzi, Y. (2023). Automated Segmentation of the Mouse Body Language to Study Stimulus-Evoked Emotional Behaviors. eNeuro, 10(9), ENEURO.0514-22.2023. https://doi.org/10.1523/ENEURO.0514-22.2023.
Chelini G.*, Pangrazzi L., & Bozzi Y. (2022). At the Crossroad Between Resiliency and Fragility: A Neurodevelopmental Perspective on Early-Life Experiences. Frontiers in cellular neuroscience, 16, 863866. https://doi.org/10.3389/fncel.2022.863866.
Chelini, G., Zerbi, V., Cimino, L., Grigoli, A., Markicevic, M., Libera, F., Robbiati, S., Gadler, M., Bronzoni, S., Miorelli, S., Galbusera, A., Gozzi, A., Casarosa, S., Provenzano, G., & Bozzi, Y. (2019). Aberrant Somatosensory Processing and Connectivity in Mice Lacking Engrailed-2. The Journal of neuroscience: the official journal of the Society for Neuroscience, 39(8), 1525–1538. https://doi.org/10.1523/JNEUROSCI.0612-18.2018.
Chelini, G., Pantazopoulos, H., Durning, P., & Berretta, S. (2018). The tetrapartite synapse: a key concept in the pathophysiology of schizophrenia. European psychiatry: the journal of the Association of European Psychiatrists, 50, 60–69. https://doi.org/10.1016/j.eurpsy.2018.02.003.
Complete publication list of Dr. Chelini is available at the following link:
https://orcid.org/0000-0001-6654-4332