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Martano Giuseppe

martano
Research scientist
URT c/o Humanitas Research Hospital
Via Manzoni 56
20089 Rozzano
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Metabolism is one of the key features of life. In our everyday life we experience it each time we move or even think to move or simply while thinking. Human brain is especially good in exploiting the metabolism as far as with only 2% of the total body weight consumes approximately 20% of the basal metabolic rate. We now known that among various brain regions, we have many differences in the metabolic composition. However, the reason why those variation occurs and how those variations contribute to generate a thought is less understood.

To answer to those questions, my research strategy is based on two pillars:

  • methodological development: Developing new bioinformatics tools, and analytical methods enabling to deeply and robustly explore the brain metabolome.
  • biological applications: Applying the developed tools for the understanding of brain biochemistry.

 

If you are a young motivated scientist, and you got interest in joining this research field please contact me by email for options.

 

   

Representative publications

Martano, G., Borroni, E. M., Lopci, E., Cattaneo, M. G., Mattioli, M., Bachi, A., Decimo, I., & Bifari, F. (2019). Metabolism of Stem and Progenitor Cells: Proper Methods to Answer Specific Questions. Frontiers in Molecular Neuroscience, 12.

Lotfi, P., Tse, D. Y., Di Ronza, A., Seymour, M. L., Martano, G., Cooper, J. D., Pereira, F. A., Passafaro, M., Wu, S. M., & Sardiello, M. (2018). Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy, 14(8), 1419-1434.

Martano, G., Gerosa, L., Prada, I., Garrone, G., Krogh, V., Verderio, C., & Passafaro, M. (2017). Biosynthesis of astrocytic trehalose regulates neuronal arborization in hippocampal neurons. ACS Chemical Neuroscience, 8(9), 1865-1872.

Martano, G., Murru, L., Moretto, E., Gerosa, L., Garrone, G., Krogh, V., & Passafaro, M. (2016). Biosynthesis of glycerol phosphate is associated with long-term potentiation in hippocampal neurons. Metabolomics, 12(8), 133.