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Murru Luca

Dettagli
Visite: 2421

me.jpgResearch scientist
c/o Università di Milano - Bicocca
Via Raoul Follereau, 3
20854 Vedano al Lambro (MB)
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Tel. 02 64488387

   

 

Neurophysiology of neurodevelopmental disorders

 

Mutations in many genes have been linked to increased risk of developing neurodevelopmental disorders (NDDs) such as intellectual disability (ID), autism spectrum disorders (ASD) and infantile neuronal ceroid lipofuscinosis (INCL). Often, these pathologies share clinical and genetic components with different neuropsychiatric disorders resulting in high comorbidity.

Nowadays, one of the main causes of NDDs pathophysiology is considered to be the alteration of the Excitation/Inhibition (E/I) balance, that leeds to aberrant neuronal functions and brain connectome. Indeed, our brain, in order to work properly, needs a fine tuning of excitatory and inhibitory signals, and a balanced E/I ratio is fundamental to obtain a proper brain maturation and function, in terms of synapse formation and brain wiring. However, our knowledge on the underlying neurophysiological mechanisms at the basis of a proper brain development is still insufficient.

murru sito

For these reasons, the main goal of my research is to better understand how brain functions and connections are altered in genetic models of NDDs, such as ASD and Infantile Neuronal Ceroid Lipofuscinosis (INCL). For this purpose I mainly use cutting-edge techniques in the field of electrophysiology.

Selected pubblications

Longatti A, Ponzoni L, Moretto E, Giansante G, Lattuada N, Colombo MN, Francolini M, Sala M, Murru L*, Passafaro M*. Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice. Mol Neurobiol. 2021 Dec;58(12):6092-6110. doi: 10.1007/s12035-021-02502-x.

Murru L#, Ponzoni L, Longatti A, Mazzoleni S, Giansante G, Bassani S, Sala M, Passafaro M. Lateral habenula dysfunctions in Tm4sf2-/y mice model for neurodevelopmental disorder. Neurobiol Dis. 2021 Jan;148:105189. doi: 10.1016/j.nbd.2020.105189. Epub 2020 Nov 20.

Murru L, Vezzoli E, Longatti A, Ponzoni L, Falqui A, Folci A, Moretto E, Bianchi V, Braida D, Sala M, D'Adamo P, Bassani S, Francolini M, Passafaro M. Pharmacological Modulation of AMPAR Rescues Intellectual Disability-Like Phenotype in Tm4sf2-/y Mice. Cereb Cortex. 2017 Nov 1;27(11):5369-5384. doi: 10.1093/cercor/bhx221.

Moretto E*, Murru L*, Martano G, Sassone J, Passafaro M. Glutamatergic synapses in neurodevelopmental disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt B):328-342. doi: 10.1016/j.pnpbp.2017.09.014. Epub 2017 Sep 19.

*Equal contributors

#Corresponding author