c/o Complesso Biologico Interdipartimentale
Viale Giuseppe Colombo 3
My research in the field of Neuroscience focuses on the role of the bi-directional communication between neurons and astrocytes in brain functioning. The close cooperation between these two cellular populations finely shapes the activity of neuronal circuits in physiological conditions and also contributes to brain disorders, including epilepsy and Alzheimer's disease. By using an electrophysiological approach in brain slices combined with calcium imaging techniques and adeno-associated viral tools, the current goal of my research is to study how astrocytes can regulate synaptic transmission in the ventral tegmental area, a dopaminergic region involved in the cerebral mechanisms of reward, aversion, motivation and addiction. The final goal of this study is to determine how the astrocyte activity participates to the animal behavior driven by this dopaminergic region.
Gómez-Gonzalo M, Zehnder T, Requie, LM, Bezzi P, Carmignoto G. (2018) Glia, doi: 10.1002/glia.23473. “Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents”
Gómez-Gonzalo M*, Martín-Fernández M*, Martínez-Murillo R*, Mederos S, Hernández-Vivanco A, Jamison S, Fernández AP, Serrano J, Calero P, Futch HS, Corpas R, Sanfeliu C, , Perea G, Araque A. (2017) Glia, doi: 10.1002/glia.23112. “Neuron-astocyte signalling is preserved in the ageing brain”
Gómez-Gonzalo M*, Navarrete M*, Perea G*, Covelo A*, Martín-Fernández M, Shigemoto R, Luján R, Araque A. (2015) Cerebral Cortex, doi:10.1093/cercor/bhu231. “Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission”.
Gómez-Gonzalo M, Losi G, Sato SS, Ratto GM, Carmignoto G. (2011) Front. Cell. Neurosci., doi: 10.3389/fncel.2011.00008. “Ictal but not interictal epileptic discharges activate astrocyte endfeet to elicit cerebral arteriole responses”.
Gómez-Gonzalo M*, Losi G*, Chiavegato A, Zonta M, Cammarota M, Brondi M, Vetri F, Uva L, Pozzan T, de Curtis M, Ratto GM, Carmignoto G. (2010) PLoS Biol., doi: 10.1371/journal.pbio.1000352. “An excitatory loop with astrocytes contributes to drive neurons to seizure threshold”.
* These authors contributed equally to this work.