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Corradini Irene

IreneResearch scientist
URT c/o Humanitas Research Hospital
Via Manzoni 56
20089 Rozzano

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Research Interests

My research activity aims at understanding the molecular mechanisms at the basis of synapse dysfunction, with a special focus on the impact of inflammation in this process.
I participated in the identification of the role of the SNARE protein SNAP-25 in the modulation of calcium channels and network excitability and the demonstration that reduced protein levels impact cognitive processes.
More recently, I contributed in investigating how prenatal immune activation impacts synapse formation and function, and in particular whether it affects the excitatory versus inhibitory balance in neurotransmission, which is one common trait shared by different neurodevelopmental diseases.

Representative Publications

Pozzi D, Rasile M, Corradini I, Matteoli M. Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on? Transl Psychiatry. 2020 Oct 15;10(1):349. doi: 10.1038/s41398-020-01027-6.

Corradini I, Focchi E, Rasile M, Morini R, Desiato G, Tomasoni R, Lizier M, Ghirardini E, Fesce R, Morone D, Barajon I, Antonucci F, Pozzi D, Matteoli M. Maternal immune activation delays excitatory-to-inhibitory GABA switch in the offspring. Biological Psychiatry, 2018 Apr 15;83(8):680-691. doi: 10.1016/j.biopsych.2017.09.030.

Filipello F*, Morini R*, Corradini I, Zerbi V, Canzi A, Michalski B, Erreni M, Markicevic M, Starvaggi-Cucuzza C, Otero K, Piccio L, Cignarella F, Perrucci F, Tamborini M, Genua M, Rajendran L, Menna E, Vetrano S, Fahnestock M, Paolicelli RC, Matteoli M. The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.Immunity. 2018 May 15;48(5):979-991.e8. doi: 10.1016/j.immuni.2018.04.016 (*equal contribution)

Tomasoni R, Morini R, Lopez-Atalaya JP, Corradini I, Canzi A, Rasile M, Mantovani C, Pozzi D, Garlanda C, Mantovani A, Menna E, Barco A, Matteoli M. Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects. Elife. 2017 Mar 28;6. pii: e21735. doi: 10.7554/eLife.21735.

Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, Brambilla R, Turco E, Rosenblum K, Wanker EE, Ziv NE, Menna E, Matteoli M. Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.Cell Death Differ. 2015 Sep;22(9):1425-36. doi: 10.1038/cdd.2014.227. Epub 2015 Feb 13.

Corradini I, Donzelli A, Antonucci F, Welzl H, Loos M, Martucci R, De Astis S, Pattini L, Inverardi F, Wolfer D, Caleo M, Bozzi Y, Verderio C, Frassoni C, Braida D, Clerici M, Lipp HP, Sala M, Matteoli M. Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs. Cereb Cortex. 2014 Feb;24(2):364-76. doi: 10.1093/cercor/bhs316. Epub 2012 Oct 12.

Corradini I, Verderio C, Sala M, Wilson MC, Matteoli M. SNAP-25 in neuropsychiatric disorders. Ann N Y Acad Sci. 2009 Jan;1152:93-9. doi: 10.1111/j.1749-6632.2008.03995.x.