Senior research scientist
Via Madonna del Piano,10
50019 - Sesto Fiorentino (FI)
Neuroepidemiology section (Florence)
Marzia Baldereschi, MD, studies causes and consequences of major age-associated neurological diseases: dementia, Alzheimer’s diseases, Parkinson’s disease, polyneuropathies, and stroke.
Research is conducted using large epidemiologic studies, which allow us to test in the general population, hypotheses on risk/protective factors and mechanisms identified by basic and clinical research.
Studies focus on estimating the actual frequencies of neurological diseases in the population and on understanding the contribution of metabolic, vascular, hormonal, professional exposures, etc. to such diseases, as well as investigating the link between neurological diseases and other common conditions of old age (hypertension, diabetes, etc.).
Significance to patient care: Research into risk or protective factors for neurological diseases, such as Parkinson's disease, dementia or stroke, will help prevent and better treat these diseases.
For more than 20 years Marzia Baldereschi worked at the CNR-PF Invecchiamento to develop the neurologic component in the ILSA (Italian Longitudinal Study on Aging) study, a large prospective cohort study on chronic diseases in the elderly.
Currently, Marzia Baldereschi has been involved into stroke promotional activities to increase stroke knowledge and awareness in the general population. She has been working with Dept. of Health of Regione Toscana to develop the 2014 Stroke Educational Campaign. She has also worked to develop the first Italian stroke application for smartphone, tablet and PC (ICTUS3R)
Project FAI: la Fibrillazione Atriale in Italia (Atrial Fibrillation in Italy). A cooperative study with GPs, to guarantee cost-effective treatments to patients with atrial fibrillation, aiming at reducing the risk of stroke.
Stroke case management: implementing comprehensive stroke care
Promotion and Implementation of Stroke Care in Italy Project
How to guarantee adherence to effective interventions in stroke care
Italian Longitudinal Study on Aging (ILSA Study)
European Implementation Score - EIS
European Registers of Stroke (EROS)
Baldereschi M, Di Carlo A, Vaccaro C, Polizzi B, Inzitari D; The Promotion Implementation of Stroke Care in Italy Project Working Group. Stroke Knowledge in Italy. Neurol Sci 2015; 36:415-421.
Baldereschi M, Di Carlo A, Vaccaro C, Toni D, Polizzi B, Inzitari D; for the Promotion and Implementation of Stroke Care in Italy Project Working Group. Stroke units in Italy: engaging the public in optimizing existing resources. Eur J Neurol 2014;21(5):791-796.
Rasura M, Baldereschi M, Di Carlo A, Di Lisi F, Patella R, Piccardi B, Polizzi B, and Inzitari D,for the Promotion and Implementation of Stroke Care in Italy Project Working Group*. Effectiveness of public stroke educational interventions: a review. Eur J Stroke 2014; 21:11-20.
Baldereschi M, Inzitari M, Di Carlo A, Bovis F, Maggi S, Capurso A, Solfrizzi V, Panza F, Scafato E, Inzitari D; ILSA Working Group. Vascular factors predict polyneuropathy in a non-diabetic elderly population. Neurol Sci 2013; 34:955-962.
Baldereschi M, Piccardi B, Di Carlo A, Lucente G, Guidetti D, Consoli D, Provinciali L, Toni D, Sacchetti ML, Polizzi BM, Inzitari D. Relevance of Prehospital Stroke Code Activation for Acute Treatment Measures in Stroke Care: A Review. Cerebrovasc Dis 2012 Sep 18;34:182-190.
Baldereschi M, Inzitari M, Di Carlo A, Farchi G, Scafato E, Inzitari D. for the ILSA Working Group. Epidemiology of distal symmetrical neuropathies in the Italian elderly. Neurology 2007;68:1460-1467.
Baldereschi M, Di Carlo A, Vanni P, Ghetti A, Carbonin P, Amaducci L, Inzitari D, for the Italian Longitudinal Study on Aging Working Group. Lifestyle-related risk factors for Parkinson’s disease: a population-based study. Acta Neurol Scand 2003;108:239-244.
Baldereschi M, Di Carlo A, Rocca WA, Vanni P, Maggi S, Perissinotto E, Grigoletto F, Amaducci L, Inzitari D, for the ILSA Working Group. Parkinson’s disease and parkinsonism in a longitudinal study: two fold higher incidence in men. Neurology 2000; 55:1358-1363.
Baldereschi M, Di Carlo A, Maggi S, Grigoletto F, Scarlato G, Amaducci L, Inzitari D. Dementia is a major predictor of death among the Italian elderly. Neurology 1999;52:709-713.
Baldereschi M, Di Carlo A, Lepore V, Bracco L, Maggi S, Grigoletto F, Scarlato G, Amaducci L, for the ILSA Working Group. Estrogen replacement therapy and Alzheimer’s disease in the Italian Longitudinal Study on Aging. Neurology 1998;50:996-1002.
Baldereschi M, Amato MP, Nencini P, Pracucci G, Lippi A, Amaducci L, Gauthier S, Beatty L, Quiroga P, Klassen G, Galea A, Muscat P, Osuntokun B, Ogunniyi A, Portera-Sanchez A, Bermejo F, Hendrie H, Burdine V, Brashear A, Farlow M, Maggi S, Katzman R. Cross-national interrater agreement on the clinical diagnostic criteria for dementia. Neurology 1994;44:239-242.