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Caleo Matteo

Matteo CaleoDirector of research
Via Giuseppe Moruzzi, 1
56124 - Pisa
Tel 050-3153195
Fax 0503153220
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Plasticity in pathology

Research summary

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The main goal of the laboratory is to characterize the plastic modifications of neuronal connections that underlie development and function of the central nervous system. The laboratory has a strong expertise in activity-dependent development and plasticity of the rodent visual system. Recently, the range of topics and techniques has expanded to include studies on different brain pathological conditions (stroke, brain tumors, epilepsy). A characteristic feature of the laboratory is the exploitation of specific bacterial toxins (such as botulinum neurotoxins, tetanus neurotoxin, and cytotoxic necrotizing factors) for studies of brain physiology and pathology. Our research relies on combining different electrophysiological (single unit, field potential and EEG recordings), neuroanatomical, behavioral and neurochemical approaches in vivo.

 

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Currently, research in the lab can be divided into five themes:

  • Neural plasticity during development and neurodevelopmental disorders
  • Mechanisms of action of clostridial neurotoxins such as botulinum neurotoxin A (BoNT/A)
  • Neuroplasticity in focal stroke and effects of robotic rehabilitation
  • Novel therapeutic approaches for glioma
  • Models of seizures and epilepsy

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Detailed research activity
People
Publications
Collaborations
Past members

 

Representative publications (since 2009)

(*, equal contribution as senior authors)

Deidda G, Allegra M, Cerri C, Naskar S, Bony G, Zunino G, Bozzi Y, Caleo M*, Cancedda L* (2015).
Early depolarizing GABA controls critical period plasticity in the rat visual cortex. Nat Neurosci 18(1): 87-96.

Mazzocchio R, Caleo M (2015). More than at the neuromuscular synapse: actions of botulinum neurotoxin A (BoNT/A) in the central nervous system. Neuroscientist 21(1):44-61.

Lai S, Panarese A, Spalletti C, Alia C, Ghionzoli A, Caleo M*, Micera S* (2015). Quantitative kinematic characterization of reaching impairments in mice after a stroke. Neurorehabil Neural Repair 29(4):382-92.

Pietrasanta M, Restani L, Cerri C, Olcese U, Medini P, Caleo M (2014). A switch from inter-ocular to inter-hemispheric suppression following monocular deprivation in rat visual cortex. Eur J Neurosci 40(1): 2283-2292.

Vannini E, Panighini A, Cerri C, Fabbri A, Lisi S, Pracucci E, Benedetto N, Vannozzi R, Fiorentini C, Caleo M*, Costa M* (2014). The bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model. BMC Cancer 14: 449.

Spalletti C, Lai S, Mainardi M, Panarese A, Ghionzoli A, Alia C, Gianfranceschi L, Chisari C, Micera S, Caleo M (2014).
A robotic system for quantitative assessment and post-stroke training of forelimb retraction in mice. Neurorehabil Neural Repair 28(2): 188-196.

Corradini I, Donzelli A, Antonucci F, Welzl H, Loos M, Martucci R, De Astis S, Pattini L, Inverardi F, Wolfer D, Caleo M, Bozzi Y, Verderio C, Frassoni C, Braida D, Clerici M, Lipp HP, Sala M, Matteoli M (2014). Epileptiform Activity and Cognitive Deficits in SNAP-25+/- Mice are Normalized by Antiepileptic Drugs. Cereb Cortex 24(2): 364-76.

Allegra M, Genovesi S, Maggia M, Cenni MC, Zunino G, Sgadò P, Caleo M*, Bozzi Y* (2014). Altered GABAergic markers, increased binocularity and reduced plasticity in the visual cortex of Engrailed-2 knockout mice. Front Cell Neurosci 8: 163.

Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B (2013). A synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjug Chem 24(10): 1750-1759.

Restani L, Giribaldi F, Manich M, Bercsenyi K, Menendez G, Rossetto O, Caleo M, Schiavo G (2012). Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons. PLoS Pathog 8(12): e1003087.

Restani L, Novelli E, Bottari D, Leone P, Barone I, Galli-Resta L, Strettoi E, Caleo M (2012). Botulinum neurotoxin A (BoNT/A) impairs neurotransmission following retrograde transynaptic transport. Traffic 13(8): 1083-9.

Mainardi M, Pietrasanta M, Vannini E, Rossetto O, Caleo M (2012). Tetanus neurotoxin-induced epilepsy in mouse visual cortex. Epilepsia 53(7): e132-6.

Cappello S, Böhringer CR, Bergami M, Conzelmann K-K, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Götz M (2012). A Radial Glia-Specific Role of RhoA in Double Cortex Formation. Neuron 73(5): 911-24.

Restani L, Antonucci F, Gianfranceschi L, Rossi C, Rossetto O, Caleo M (2011). Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A). J Neurosci 31(44): 15650-15659.

Cerri C, Fabbri A, Vannini E, Spolidoro M, Costa M, Maffei L, Fiorentini C, Caleo M (2011). Activation of Rho GTPases triggers structural remodeling and functional plasticity in the adult rat visual cortex. J Neurosci 31(42): 15163-72.

Cerri C, Restani L, Caleo M (2010). Callosal contribution to ocular dominance in rat primary visual cortex. Eur J Neurosci 32(7): 1163-1169.

Antonucci F, Cerri C, Maya Vetencourt JF, Caleo M (2010). Acute neuroprotection by the synaptic blocker botulinum neurotoxin E in a rat model of focal cerebral ischaemia. Neuroscience 169(1):395-401.

Restani L, Cerri C, Pietrasanta M, Gianfranceschi L, Maffei L, Caleo M (2009). Functional masking of deprived eye responses by callosal input during ocular dominance plasticity. Neuron 64(5): 707-718.

Caleo M (2009). Epilepsy: synapses stuck in childhood. Nat Med 15(10): 1126-1127.

Pinto L, Drechsel D, Schmid M-T, Ninkovic J, Irmler M, Brill MS, Restani L, Gianfranceschi L, Cerri C, Weber SN, Tarabykin V, Baer K, Guillemot F, Beckers J, Zecevic N, Dehay C, Caleo M, Schorle H, Gotz M (2009).  AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat Neurosci 12(10): 1229-1237.